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Study identifies a new potential target for treating vascular disease

Study identifies a new potential target for treating vascular disease
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United States , Sherie Kelemen , Amandam Peluzzo , Michaelv Autieri , Satoru Eguchi , Rachaeln Okune , Dales Haines , Tani Leigh , Department Of Cardiovascular Sciences , World Health Organization , American Society For Investigative Pathology , National Heart , Elsevier Foundation , Blood Institute , American Journal , Cardiovascular Sciences , Lewis Katz School , Temple University , Intimal Hyperplasia , Induces Senescence , Vascular Smooth Muscle Cells , American Society , Investigative Pathology , Diversity Advisory Board , Press Release Image , Fragile X ,

Study identifies a new potential target for t

Vascular diseases, including myocardial infarction, stroke, renal failure, and peripheral vascular disease, continue to account for one third of all mortality in the United States, Europe, and the developing world (World Health Organization, 2021). Vascular smooth muscle cell (VSMC) activation plays a crucial role in the development of multiple vascular diseases. In a novel study in The American Journal of Pathology, published by Elsevier, researchers found that when fragile-X related protein-1 (FXR1) is absent, VSMC proliferate more slowly, become senescent, and scar tissue (neointima) development is reduced. Therefore, drugs targeting FXR1 may treat vascular proliferative diseases. ....

United States , Michaelv Autieri , World Health Organization , Method Of Research , Department Of Cardiovascular Sciences , American Journal , Cardiovascular Sciences , Lewis Katz School , Temple University , Intimal Hyperplasia , Induces Senescence , Vascular Smooth Muscle ,

Pigment epithelium-derived factor ablations may lead to eye aging

Researchers identified that loss of pigment epithelium-derived factor (PEDF) may cause aging in the eye. ....

International Journal Of Molecular Sciences , International Journal , Molecular Sciences , Induces Senescence ,