Dengue virus infection is prevalent in tropical and sub-tropical regions of the world, which is fatal if untreated symptomatically. Emergence of new genotype within serotypes led to enhanced severity. The objective of the study is to identify the molecular characteristics of the DENV circulated during 2017 outbreak in Tamil Nadu, India and, to investigate the role of inflammatory cytokines in different ‘serotypes’ and in ‘dengue severity’. A total of 135 suspected samples were tested for DENV infection using IgM, IgG and qPCR assay; where 76 samples were positive for DENV and analysed for twelve inflammatory cytokines using ELISA. Serotyping shows 14 DENV-1, 22 DENV-2, 7 DENV-3 and 33 DENV-4, where DENV-4 was predominant. Among seventy-six, forty-two isolates were successfully sequenced for C-prM region and grouped. A lineage shift was observed in DENV-4 genotype. Irrespective of serotypes, IFNγ was significantly elevated than control and in primary infection indicating its ro
Letzter Supermond 2021 – Weshalb der Vollmond in der Schweiz kein Blutmond ist
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Erster Supermond 2021 – Wieso der Vollmond heute Nacht «pink» ist
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Indian Strains of COVID Could Be More Infectious: AIIMS Chief
Dr Randeep Guleria added that the new strain is “highly transmissible and dangerous” and could cause re-infections.
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As reports of a new strain of coronavirus in Maharashtra emerge, AIIMS Chief, Dr Randeep Guleria on Saturday, 20 February, told NDTV that herd immunity, especially in the case of the new Indian strains – found in Amravati and Akola – is a “myth” because at least 80 percent of the population needs to have developed anti-bodies to fight the virus.
The doctor added that the new strain is “highly transmissible and dangerous” and could cause re-infections for those who have previously developed anti-bodies. Guleria attributed the re-infections to “immune escape mechanism” of variants of the virus.