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Getting under skin of an autoimmune disorder

Getting under skin of an autoimmune disorder
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Fadi Kharouf , Sigal Grisariu , Daniel Kirschenbaum , Richard Jacqui Scheinberg , Gadi Moshe , Shlomit Erenfeld , Suhail Aamar , Baoguo Li , Eyal David , Ido Amit , Dalit Amar , Yoseph Addadi , Tehila Tzemach , Mor Zada , Chamutal Gur , Reut Tzemach , Dana Hirsch , Meir Salame , Batia Avni , Diego Adhemar Jaitin , Adam Jelinski , Oren Barboy , Fadi Sheban , Yolanda Braun Moscovici , Chamutal Bornstein , Vered Molho Pessach ,

Accurate evaluation of CRISPR genome editing

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CRISPR technology allows researchers to edit genomes by altering DNA sequences and by thus modifying gene function. Its many potential applications include correcting genetic defects, treating and preventing the spread of diseases and improving crops.
Genome editing tools, such as the CRISPR-Cas9 technology, can be engineered to make extremely well-defined alterations to the intended target on a chromosome where a particular gene or functional element is located. However, one potential complication is that CRISPR editing may lead to other, unintended, genomic changes. These are known as off-target activity. When targeting several different sites in the genome off target activity can lead to translocations, unusual rearrangement of chromosomes, as well as to other unintended genomic modifications. ....

Daniel Allen , Garrettr Rettig , Anavy Technion , Mark Behlke , Ido Amit , Ayal Hendel , Chihong Choi , Nimrod Ben Haim , Matthews Mcneil , Zohar Yakhini , Gavin Kurgan , Jurgenson Technion , Ortal Iancu , Hendel Lab , Nature Communications , Yakhini Research Group , Ilan University , Everard Goodman Faculty Of Life Sciences , Ilan University Mina , Technologies Inc , Hendel Lab At Bar , Interdisciplinary Center Herzliya , European Research Council , Bar Ilan University , Next Generation Sequencing , Everard Goodman Faculty ,

New immune players involved in metabolic liver disease

New immune players involved in metabolic liver disease
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Eyal David , Richard Jacqui Scheinberg , Mathias Heikenwaelder , Ido Amit , Aleksandra Deczkowska , Assaf Weiner , Lady Tania Feldmann , Wolfson Family Charitable Trust Foundation , Harryb Helmsley Charitable , Moross Integrated Cancer Center , Joycee Eisenberg Foundation , Weizmann Institute Of Science , Normane Alexander Familym Foundation , German Cancer Research Center , Penny Myers Foundation , Valeria Rosenbloom Foundation , Swiss Society Institute For Cancer Prevention Research , Adelis Foundation , Joseph Nissim Center , Thompson Family Foundation Alzheimer Disease Research Fund , Coronavirus Research Fund , Mady Dukler Fund For Cancer Research , Immunology Department , Life Sciences Research , Garvan Weizmann Partnership , Irvinge Meller Center ,

Uncovering the Anti-Myeloma Resistance Files

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Multiple myeloma (a type of blood cancer) patients live much longer today than in the past, thanks to new targeted anti-myeloma drugs, but ultimately most develop resistance to the medications, and in some the disease is resistant to therapy from the start. Weizmann Institute of Science researchers, in collaboration with physicians from
Tel Aviv Sourasky Medical Center (TASMC), have made use of extremely sensitive genomic technology to reveal genetic pathways that characterize some of the more resistant cases of multiple myeloma.
Nature Medicine, may lead to a more informed, personalized treatment for these patients, and it paves the way to using this new technology for discovering additional disease targets in other cancers. ....

Mouna Ballan , Tamar Tadmor , Yaelc Cohen , Gadi Moshe , Oren Pasvolsky , Chezi Ganzel , Meirav Laiba , Chamutal Bornstein , Baoguo Li , Eyal David , Jacqui Scheinberg , Ido Amit , Assaf Weiner , Osnat Jarchowcky Dolberg , Efrat Luttwak , Noa Lavi , Mor Zada , Irit Avivi , Olga Shvetz , Chamutal Gur , Evgeni Chubar , Iuliana Vaxman , Ofer Shpilberg , Anatoly Nemets , Anita James Rosen Foundation , Moross Integrated Cancer Center ,