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Accurate evaluation of CRISPR genome editing


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CRISPR technology allows researchers to edit genomes by altering DNA sequences and by thus modifying gene function. Its many potential applications include correcting genetic defects, treating and preventing the spread of diseases and improving crops.
Genome editing tools, such as the CRISPR-Cas9 technology, can be engineered to make extremely well-defined alterations to the intended target on a chromosome where a particular gene or functional element is located. However, one potential complication is that CRISPR editing may lead to other, unintended, genomic changes. These are known as off-target activity. When targeting several different sites in the genome off target activity can lead to translocations, unusual rearrangement of chromosomes, as well as to other unintended genomic modifications. ....

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Researchers develop tool to accurately evaluate CRISPR genome editing


Researchers develop tool to accurately evaluate CRISPR genome editing
ANI |
Updated: May 24, 2021 16:31 IST
Washington [US], May 24 (ANI): During a recent study, researchers from the IDC Herzliya and Bar-Ilan University developed a novel software tool to quantify potential CRISPR-induced errors. CRISPR is the technology that allows researchers to edit genomes by altering DNA sequences and by thus modifying gene function.
The study was published in the journal Nature Communications. The many potential applications of CRISPR include correcting genetic defects, treating and preventing the spread of diseases, and improving crops.
Genome editing tools, such as the CRISPR-Cas9 technology, can be engineered to make extremely well-defined alterations to the intended target on a chromosome where a particular gene or functional element is located. ....

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IDC Herzliya, Bar-Ilan, Develop Software to Help Measure DNA Sequencing Errors | The Jewish Press - JewishPress.com | Jewish Press News Desk | 13 Sivan 5781 – May 24, 2021