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First-in-Class YAP/TEAD Inhibitor Demonstrates Early Efficacy Targeting Hippo Pathway

Investigators hope that first-in-class agents will combat dysfunction of the Hippo pathway, which promotes YAP and TAZ activation resulting in uncontrolled proliferation and impaired differentiation, by inhibiting the transcription
function of TEAD-YAP. ....

United States , Ibiayi Dagogo Jack , American Association For Cancer Research Annual Meeting , Harvard Medical School , Massachusetts General Hospital , Lung Cancer , World Conference , Cancer Research Annual Meeting , International Association , Exp Clin Cancer , Precision Medicine , Yap Tead Inhibitor , Hippo Pathway ,