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Objectives：This study investigated the antimicrobial effect and anti-inflammatory activities of PGLa-loaded TiO2 nanotube arrays (TiO2 NTs) in osteoblast-like MG-63 cells. Methods：The surface morphology and roughness of three titanium (Ti) substrates (Ti, TiO2 NTs, PGLa-loaded TiO2 NTs) were evaluated by scanning electron microscopy (SEM) and atomic force microscope (AFM). The wettability of three titanium substrates was evaluated by contact angle. Biocompatibility of PGLa-loaded TiO2 NTs were evaluated in MG-63 cells (cell adhesion, proliferation, cytoskeletal evaluation and alkaline phosphatase activity). Spread plate counting method was used to evaluate antibacterial abilities of the Ti substrates. The calcein AM/PI staining evaluated cell viability of MG-63 cells on the substrates with or without proinflammatory factors (TNF-α). Results：The average surface roughness of untreated Ti, TiO2 NTs, PGLa-loaded TiO2 NTs were found to be 135.8±6.4 nm, 300.5±10.5 nm, 348.9& ....

United States , Al Qahirah , South Africa , United Kingdom , South African , J Nanosci Nanotechnol , Wiley Interdiscip , Pgla Group , Chinese Academy Of Science Shanghai , Pants Group , Cell Bank , Ethics Committee Of Aerospace Center Hospital , Public Health , Foundation Of Aerospace Center Hospital , Chinese Academy , Cell Counting , Medical Ethics Committee , Aerospace Center , Aerospace Center Hospital , Grant Number , Med Abstract , Crossref Full Text , Oral Implants , Porous Tio , Surface Roughness , Cell Morphology ,