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Gut microbes are crucial for human health, which are usually accumulated in urban wastewater systems. Seven wastewater treatment plants in Australia with distinct population obesity rates between 18% and 33% were selected for wastewater sampling and analysis. Human gut microbiome were detected using metagenomic sequencing to investigate their associations with the community obesity rate. To unravel this complex relationship, a range of algorithm models, including linear discriminant analysis effect size (LEfSe), similarity percentage analysis (SIMPER), statistical analysis of metagenomic profiles (STAMP), linear models for microarray and RNA-Seq data analysis (LIMMA), Relief, ratio approach for identifying differential abundance (RAIDA), least absolute shrinkage and selection operator (LASSO), support vector machine (SVM), Boruta, DESeq2 and analysis of compositions of microbiomes with bias correction (ANCOM-BC), were used to identify potential bacterial biomarkers for obesity in the w ....
Landmark study uncovers link between gut microbes, good health and chronic illnesses The findings add to mounting evidence that gut health affects overall wellbeing in ways we don t fully understand. Jan 13, 2021 12:41:20 IST A diet that is predominant healthy and plant-based encourages a mix of good bacteria in the gut, which is linked with lower risk of common illnesses like heart disease, obesity and type-2 diabetes, new research has said. The study, published in Nature Medicine, was carried out by researchers at King s College London, Massachusetts General Hospital (MGH), Harvard T H Chan School of Public Health, the University of Trento, Italy, and health start-up company ZOE. Using genomic samples, blood chemistry profiles and detailed data about the dietary habits, gut microbiomes and metabolic markers in the blood, researchers carried out the Personalized Responses to Dietary Composition Trial 1 (PREDICT 1). ....