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E-Mail IMAGE: Human enzyme METTL3 adds methyl groups to introduce m6A in SARS-CoV-2 s RNA. That modification prevents the virus RNA from triggering inflammatory molecules known as cytokines. METTL3 also leads to increased. view more Credit: UC San Diego Health Sciences Researchers at University of California San Diego School of Medicine have discovered one way in which SARS-CoV-2, the coronavirus that causes COVID-19, hijacks human cell machinery to blunt the immune response, allowing it to establish infection, replicate and cause disease. In short, the virus genome gets tagged with a special marker by a human enzyme that tells the immune system to stand down, while at the same time ramping up production of the surface proteins that SARS-CoV-2 uses as a doorknob to enter cells. ....
News release Researchers at University of California San Diego School of Medicine have discovered one way in which SARS-CoV-2, the coronavirus that causes COVID-19, hijacks human cell machinery to blunt the immune response, allowing it to establish infection, replicate and cause disease. In short, the virus’ genome gets tagged with a special marker by a human enzyme that tells the immune system to stand down, while at the same time ramping up production of the surface proteins that SARS-CoV-2 uses as a “doorknob” to enter cells. The study, published April 22, 2021 in Cell Reports, helps lay the groundwork for new anti-viral immunotherapies treatments that work by boosting a patient’s immune system, rather than directly killing the virus. ....
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