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The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study | BMC Medicine

The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to compare the persistence of anti-Spike antibodies following two-dose SARS-CoV-2 vaccination between IMID patients and healthy controls and to identify factors associated with antibody decline. IMID patients on immunosuppressive medication enrolled in the prospective observational Nor-vaC study were included. Participants received two-dose SARS-CoV-2 vaccination. Serum collected at two time points following vaccination (first assessment within 6–48 days, second within 49–123 days) were analyzed for antibodies binding the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. Multivariable regression models estimated percent reduction in anti-RBD over 30 days and factors associated with reduction. A total of 1108 patients (403 rheumatoid arthritis, 195 psoriatic arthr ....

Division Of Rheumatology , Department Of Gastroenterology At Akershus University Hospital , Services For Sensitive Data , Norwegian Institute Of Public Health , Department Of Immunology , Oslo University Hospital , Health Research Ethics South , Diakonhjemmet Hospital , Akershus University Hospital , Regional Committees , Health Research Ethics South East , Norwegian Institute , Public Health , Sensitive Data , Mayo Score , Norwegian Immunisation Registry , Norwegian Surveillance System , Communicable Diseases , Binding Antibody Units ,

Changes in maternal risk factors and their association with changes in cesarean sections in Norway between 1999 and 2016: A descriptive population-based registry study

Changes in maternal risk factors and their association with changes in cesarean sections in Norway between 1999 and 2016: A descriptive population-based registry study
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United States , United Kingdom , Gordonc Smith , Burlo Garofolo , Manuela Giangreco , Cambridge University , Health Research Ethics South East , World Health Organization , Stata Corporation , Institute For Maternal , Regional Committee For , Arctic University Of Norway , Norwegian Society For Gynecology , Child Health , International Federation Of Gynecology , Norwegian Medical Birth Registry , Creative Commons Attribution License , Uit The Arctic University , Norwegian Society , College Station , Regional Committee , General Data Protection Regulation , Term Breech Trial , International Federation ,

Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study

Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study
Maria C. Magnus ,
Roles
Investigation,
Methodology,
Writing – review & editing
Affiliations
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway,
Department of Clinical Science, University of Bergen, Bergen, Norway,
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
⨯
Knut-Arne Wensaas,
Affiliation
Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway
Roles
Conceptualization,
Investigation,
Methodology,
Writing – review & editing
Affiliation
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Siri E. Håberg ....

City Of , United Kingdom , Jennye Myers , International Classification Of Diseases , University Of Manchester , Health Research Ethics South East , Regional Committee For , International Classification Of Primary Care , Research Council , University Of Bristol , Research Council Of Norway , Morkenn H , Wensaask A , Creative Commons , Intramural Program , National Institute , Environmental Health Sciences , Medical Research Council , Integrative Epidemiology Unit , International Classification , Primary Care , Observational Routinely Collected Data , Observational Studies , Medical Birth Registry , Norwegian Patient Registry , Supplement Methods ,