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New Study Supports COVID-19 Vaccination in Patients with Cystic Fibrosis

COVID-19 vaccination in patients with cystic fibrosis generates antibody responses similar to those in the general population, according to a recent study ....

Pediatr Pulmonol , Division Of Pulmonary , Georgene Hergenroeder , Sleep Medicine , Seattle Children , Binding Antibody Units , Rare Disease Report Podcast ,

The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study | BMC Medicine

The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to compare the persistence of anti-Spike antibodies following two-dose SARS-CoV-2 vaccination between IMID patients and healthy controls and to identify factors associated with antibody decline. IMID patients on immunosuppressive medication enrolled in the prospective observational Nor-vaC study were included. Participants received two-dose SARS-CoV-2 vaccination. Serum collected at two time points following vaccination (first assessment within 6–48 days, second within 49–123 days) were analyzed for antibodies binding the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. Multivariable regression models estimated percent reduction in anti-RBD over 30 days and factors associated with reduction. A total of 1108 patients (403 rheumatoid arthritis, 195 psoriatic arthr ....

Division Of Rheumatology , Department Of Gastroenterology At Akershus University Hospital , Services For Sensitive Data , Norwegian Institute Of Public Health , Department Of Immunology , Oslo University Hospital , Health Research Ethics South , Diakonhjemmet Hospital , Akershus University Hospital , Regional Committees , Health Research Ethics South East , Norwegian Institute , Public Health , Sensitive Data , Mayo Score , Norwegian Immunisation Registry , Norwegian Surveillance System , Communicable Diseases , Binding Antibody Units ,

Immunological factors associated with impaired BNT162b2 mRNA vaccine response in older adults

A new study posted to the pre-print server medRxiv investigated the significant immune alterations concerning SARS-CoV-2 specific innate and adaptive immunity associated with a lower BNT162b2 mRNA vaccine response in older individuals. ....

Droneandy Shutterstock , Binding Antibody Units , Coronavirus Disease Covid 19 , Covid 19 , Ars Cov 2 ,

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees

Abstract
The emergence of SARS-CoV-2 variants harboring mutations in the spike (S) protein has raised concern about potential immune escape. Here, we studied humoral and cellular immune responses to wild type SARS-CoV-2 and the B.1.1.7 and B.1.351 variants of concern in a cohort of 121 BNT162b2 mRNA-vaccinated health care workers (HCW). Twenty-three HCW recovered from mild COVID-19 disease and exhibited a recall response with high levels of SARS-CoV-2-specific functional antibodies and virus-specific T cells after a single vaccination. Specific immune responses were also detected in seronegative HCW after one vaccination, but a second dose was required to reach high levels of functional antibodies and cellular immune responses in all individuals. Vaccination-induced antibodies cross-neutralized the variants B.1.1.7 and B.1.351, but the neutralizing capacity and Fc-mediated functionality against B.1.351 was consistently 2- to 4-fold lower than to the homologous virus. In additi ....

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Researchers take steps to standardize correlates of protection against SARS-CoV-2

Researchers take steps to standardize correlates of protection against SARS-CoV-2
Researchers in the UK and Germany have identified a range of assays and biomarkers of humoral (antibody) immunity against coronavirus disease 2019 (COVID-19) that can be used to define correlates of protection in future studies.
Wherever suitable, antibody-based parameters were expressed in International Units (IU) and Binding Antibody Units (BAU).
The adoption of common results reporting unitage in IU and BAU as those described in this study would eventually facilitate comparative analyses of data generated by immunogenicity studies performed by different teams in different parts of world, says Jonathan Heeney from the University of Cambridge and colleagues. ....

United Kingdom , Sally Robertson , Jonathan Heeney , International Units , University Of Cambridge , World Health Organization , International Standard , National Health Service , Binding Antibody Units , Towards Internationally , Immune Correlates , Ars Cov 2 , Coronavirus Disease Covid 19 , ஒன்றுபட்டது கிஂக்டம் , சாலி ராபர்ட்சன் , ஜொனாதன் ஹீனி , சர்வதேச அலகுகள் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , சர்வதேச தரநிலை , தேசிய ஆரோக்கியம் சேவை ,