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Researchers discover potential new therapeutic targets on SARS-CoV-2 Spike protein


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UNIVERSITY PARK, Pa. The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.
Significant research is underway to examine how the receptor binding domain (RBD) at the tip of the club-shaped SARS-CoV-2 Spike protein attaches to an ACE2 receptor on a human cell, but little is known about the other changes that occur in the Spike protein as a result of this attachment, said Ganesh Anand, associate professor of chemistry, Penn State. We have uncovered hotspots further down on the Spike protein that are critical for SARS-CoV-2 infection and may be nov ....

National University Of Singapore , Singapore General , Xinlei Qian , Nikhilk Tulsian , Palurv Raghuvamsi , Marym Kozma , Paula Macary , Kiren Purushotorman , Gu Yue , Firdaus Samsudin , Wongy Hwa , Julien Lescar , Ganesh Anand , Nanyang Technological University , National Medical Research Council , National University , Medicine Health , Infectious Emerging Diseases , தேசிய பல்கலைக்கழகம் ஆஃப் சிங்கப்பூர் , சிங்கப்பூர் ஜநரல் , கு யூஎ , ஃப்ர்டெயாஸ் சம்ஸூதின் , கணேஷ் ஆனந்த் , தேசிய மருத்துவ ஆராய்ச்சி சபை , தேசிய பல்கலைக்கழகம் , உயிர் வேதியியல் ,