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IMAGE: Provided Anand was awarded LB2C funding for his project titled “Targeting Virus Breathing Hotspots for Antibody Discovery.” Anand looks for vulnerabilities on a virus that could be tapped to generate antibodies for use in antiviral therapies. He is particularly interested in understanding the structural changes of viral surface proteins as the virus dissembles and enters human host cells. These structural changes part of a process called viral breathing could reveal critical locations called epitopes where antibodies can bind to the virus. Anand will then work with collaborators to test the effectiveness of antibodies designed to target certain epitopes that, for example, occur across a variety of virus variants or are particularly accessible. This approach, which uniquely seeks to merge the biophysical insights of viral breathing with targeted antibody discovery, preemptively identifies new antibodies and could thus greatly advance viral pandemic prepar ....
Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein This graphic demonstrates viral entry into a host cell mediated by Spike protein-ACE2 interactions. Click on the image for more detailed information.Image: Ganesh Anand, Penn State Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein Sara LaJeunesse February 23, 2021 UNIVERSITY PARK, Pa. The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention. ....
Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
Researchers uncover 'hotspots' on the Spike protein that are critical for SARS-CoV-2 infection news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
E-Mail UNIVERSITY PARK, Pa. The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention. Significant research is underway to examine how the receptor binding domain (RBD) at the tip of the club-shaped SARS-CoV-2 Spike protein attaches to an ACE2 receptor on a human cell, but little is known about the other changes that occur in the Spike protein as a result of this attachment, said Ganesh Anand, associate professor of chemistry, Penn State. We have uncovered hotspots further down on the Spike protein that are critical for SARS-CoV-2 infection and may be nov ....