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Studying Biomedical Science at Sheffield is one of the best decisions I've ever made. | School of Biosciences

Thanks to the practical research experience that she gained on her course, Katherine is now beginning life as a PhD student at the MRC Laboratory of Molecular Biology. Katherine believes that studying Biomedical Science Sheffield was one of the best decisions that she has ever made. ....

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Frontiers | Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction



1Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States
2Molecular and Cellular Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, United States
3Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States
4Center for Translational Medicine, Temple University, Philadelphia, PA, United States
Background: Endothelial cells (ECs) play a critical role in the maintenance of vascular homeostasis and in heart function. It was shown that activated fibroblast-derived exosomes impair cardiomyocyte function in hypertrophic heart, but their effect on ECs is not yet clear. Thus, we hypothesized that activated cardiac fibroblast-derived exosomes (FB-Exo) mediate EC dysfunction, and therefore modulation of FB-exosomal contents may improve endothelial function. ....

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