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Gene-by-gene approach, diverse sample yields new AD risk genes

Investigators at the National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) have used a gene-constrained analysis to identify nine new Alzheimer’s disease (AD) risk genes that are possibly linked to the higher prevalence of AD in people with African ancestry. One of those genes, GNB5, regulates the stability of certain G protein-signaling proteins, which are activated by G protein-coupled receptors (GPCRs). The authors showed that mice with only one copy of Gnb5 developed more amyloid plaques and tau tangles than those with two copies. ....

National Institute Of Diabetes , National Institute , Kidney Disorders , Bioworld Science , Neurology Psychiatric , Alzheimers Disease , G Protein Coupled Receptors ,

IRS Provides Interim Self-Correction Guidance Under the SECURE Act 2.0

Notice 2023-43 provides helpful guidance on additional types of failures that may be self-corrected including certain demographic failures and plan loan failures that were previously ineligible. ....

Compliance Program , Employee Plans Compliance Resolution System , Eligible Inadvertent Failures , Internal Revenue Code , Inadvertent Failures , Inadvertent Eligible Failure , Eligible Inadvertent Failure , Code Section , Treasury Regulations , Voluntary Closing Agreement Procedure , Labor Amp Employment Law , Self Correction , Eligible Inadvertent Failure , Otice 2023 43 ,

Vaccinex New ActivMAb® application published in Nature Communications for Directed Evolution of GPCRs in Mammalian Cells

GPCRs play a key role in many important physiological processes which makes them an important class of drug targets; however, their biophysical properties have made many GPCRs. | April 12, 2023 ....

Ernest Smith , John Mullaly , University Of Zurich , Nature Communications , Lifesci Advisors , Exchange Commission , Vaccinex Inc , Vice President Research , Chief Scientific , Sci Advisors , Nc Stock Exchange , Press Release , Any Vcnx Us9186401033 ,

Investment to progress newly discovered Antibody Assets

Biotech Antiverse has successfully identified functional antibody clusters targeting two G-protein-coupled receptors (GPCRs), both displaying versatile binding profiles and nanomolar affinity. Click to read more. ....

Murat Tunaboylu , Ted Parkinson , Cardiff University Meditech Centre , Development Bank , Biotech Antiverse , Kadmos Capital , Tomorrow Scale , Tensor Ventures , Deep Science Ventures , Cardiff University , Meditech Centre ,

OKYO Pharma LTD: OKYO Pharma to Present at the Second Annual GPCRs-Targeted Drug Discovery Summit in Boston, MA on February 21-23, 2023.

LONDON and NEW YORK, Feb. 21, 2023 (GLOBE NEWSWIRE) OKYO Pharma Limited (LSE: OKYO; NASDAQ: OKYO) ("OKYO", "OKYO Pharma" or the "Company"), an ophthalmology-focused bio-pharmaceutical company which ....

United States , United Kingdom , City Of , Dennis Riedl , Robert Emmet , Paul Spencer , Alan Kopin , Garys Jacob , London Stock Exchange , Pharma Limited , Drug Administration , Optiva Securities , Novel Therapeutic , Targeted Drug Discovery Summit , Hyatt Regency , Chief Scientific Officer , Target Therapeutics , Investigational New Drug , Official List , United Kingdom Financial Conduct Authority , Chief Executive Officer , Chief Executive ,