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Jennifer Miller, PhD, associate professor of medicine (general medicine), specializes in developing and using metrics to enhance accountability and social ....
As companies prepare for the 2023 proxy season, their ESG performance, as evaluated and rated by various third-party ratings providers, is a key focus. With the growing importance of. ....
Author summary Why was this study done? ➢ Clinicians and researchers depend on the peer-reviewed literature for accurate assessments of drug efficacy and safety, but this depends on whether the outcomes of all trials—negative, as well as positive—are reported transparently. ➢ In an earlier study, using Food and Drug Administration (FDA) review documents as a gold standard, we found that many negative trials had been misreported in the published literature as having positive outcomes or had simply not been published. ➢ Since then, reporting bias has been the subject of additional studies and policy changes, raising the question, Is the antidepressant literature now being reported more transparently? What did the researchers do and find? ➢ Using FDA reviews on 4 newer antidepressants, we identified 30 trials, half with positive, and half with negative, outcomes. ➢ Among the 15 negative trials, 6 were unpublished and 2 others were misre ....