<p>In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing. Their findings, published in <em>Nature</em>, uncover detailed information that could help overcome the limitations of today’s immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer. </p>