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Steep LDL Cholesterol Reductions With ANGPTL3 siRNA in HoFH

A single injection every 3 months of a novel drug that targets the lipid metabolism enzyme ANGPTL3 resulted in substantial reductions in LDL cholesterol in patients with HoFH in the phase 2 GATEWAY trial. ....

South Africa , Baden Wüberg , G Danilo Norata , Frederickj Raal , Department Of Pharmacological , Lipid Metabolism Research Unit , Biomolecular Sciences , Arrowhead Pharmaceuticals , University Of The Witwatersrand , European Atherosclerosis Society , Drug Administration , University Of Milan , Regeneron Pharmaceuticals , Medscape Cardiology , Ipid Management , Low Ldl Cholesterol , Ow Low Density Lipoprotein Cholesterol , Liver Enzymes , Liver Studies , Roprotein Convertase Subtilisin Kexin Type 9 , High Density Lipoprotein Cholesterol , Fdl C , Genomic Medicine , Edicine Genomic , Genetic Testin ,

Familial, Early-Onset T2D Shows Distinct Profile

A case-control study of 178 patients in China with early-onset type 2 diabetes and either a multigenerational family history or no history of this disease showed between-group clinical differences. ....

Diabetes Mellitus Type 2 , Iabetes Mellitus Type Ii , Type 2 Diabetes , Diabetes Mellitus , Hemoglobin A1c , Hemoglobin A1c Test , Glycated Hemoglobin , Glycosylated Hemoglobin , Iabetic Control Index , 1c Assay , Genomic Medicine , Edicine Genomic , Peer Review , Body Mass Index Bmi , Dna Sequencing , Genetic Testin ,