An international collaboration led by USC explored the genomes of nearly 950,000 men, finding a total of 451 variants and refining what is known about genetic risk for prostate cancer. A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with pr
<p style="text-align:start">A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk — 451 in all — through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet. The research explored the genomes of nearly 950,000 men, including major increases in representation among men from racial and ethnic groups that have often been left out of such research. The study identified 187 new genetic variants linked to prostate cancer, revising what is known about genetic risk for the disease. With these findings, the researchers improved a system they developed for measuring genetic risk so that it was more effective in predicting who would or wouldn’t develop prostate cancer — even distinguishing between the likelihood of aggressive and less-serious cases among men of African descent.</p>
<p>Researchers have found that previous studies analyzing the genomes of people with European ancestry may have reported inaccurate results by not fully accounting for population structure. By considering mixed genetic lineages, researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, demonstrated that previously inferred links between a genomic variant that helps digest lactose and traits such as a person’s height and cholesterol level may not be valid.</p>
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