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Dr Melstrom on Challenges Implementing Widespread Molecular Testing in GI Cancer

Laleh Melstrom, MD, MS, discusses using molecular testing to guide treatment selection for patient with gastrointestinal cancers. ....

Laleh Melstrom , Department Of Surgery , Division Of Surgical Oncology , Surgical Oncology , Molecular Testing , City Of Hope ,

Functional Gastrointestinal Disorders

Functional gastrointestinal disorders (FGID) are common disorders associated with persistent and recurrent gastrointestinal (GI) symptoms. Several studies have indicated that stress and psychological difficulties make FGID worse. This article focuses on the physiological and psychological aspects of FGID. ....

Poptika Shutterstock , Rome Foundation Global Study , Jerome Foundation , Image Credit , Cognitive Behavioural Therapy , Functional Gastrointestinal Disorders , Rome Foundation Global , Children Increases , Matched Cohort , Gastrointestinal Disorders ,

Targeting CTLA-4 without colitis induction is gut microbiota dependent

Immune checkpoint inhibitors (ICIs), such as anti-CTLA-4 antibodies, are widely used in cancer immunotherapy. CTLA-4 blockers such as Yervoy (ipilimumab, Bristol Myers Squibb Co.) stimulate antitumoral immune responses, but may also induce toxicity, such as colitis, a common immune-related adverse event that can lead to treatment discontinuation. ....

Bristol Myers Squibb Co , Immuno Oncology , Bioworld Science , Gut Microbiota , Ctla 4 , University Of Michigan , Anti Ctla 4 Nanobodies , Fc Domain ,