Front Cell News Today : Breaking News, Live Updates & Top Stories | Vimarsana
Stay updated with breaking news from Front cell. Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.
Top News In Front Cell Today - Breaking & Trending Today
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits variable immunity responses among hosts based on symptom severity. Whether immunity in recovered individuals is effective for avoiding reinfection is poorly understood. Determination of immune memory status against SARS-CoV-2 helps identify reinfection risk and vaccine efficacy. Hence, after recovery from COVID-19, evaluation of protective effectiveness and durable immunity of prior disease could be significant. Recent reports described the dynamics of SARS-CoV-2 -specific humoral and cellular responses for more than six months in convalescent SARS-CoV-2 individuals. Given the current evidence, NK cell subpopulations, especially the memory-like NK cell subset, indicate a significant role in determining COVID-19 severity. Still, the information on the long-term NK cell immunity conferred by SARS-CoV-2 infection is scant. The evidence from vaccine clinical trials and observational studies indicates that hybrid natural/ ....
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there has long been evidence that the immune system is not completely incapable of responding to M. ulcerans infection. In particular, IL-1beta was recently shown to be present in BU lesions, and to be induced from M. ulcerans-exposed macrophages in a mycolactone-dependent manner. This has important implications for our understanding of BU, showing that mycolactone can act as the “second signal” for ....
“When experiencing a stressful event, the area of the brain that controls emotions, the amygdala, sends a distress signal to the hypothalamus, the brain’s command center,” explained Lucie Lingrand, a brain-gut axis specialist and product manager at Lallemand Health Solutions. “The hypothalamus then sends out an alert through the nervous system, which responds by releasing a flood of stress hormones, including adrenaline and cortisol.” As the fight-or-flight response kicks in, digestion slows and gut sensitivity is increased. “Many studies in animal models of stress, as well as acute or chronic stress in human models, have shown that the intestinal barrier is impaired and that the composition of the gut microbiota is changed,” ....