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Euclid University convocation honours late VP Joof

Euclid University convocation honours late VP Joof
thepoint.gm - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thepoint.gm Daily Mail and Mail on Sunday newspapers.

Pierre Gomez , Robin Van Puyenbroeck , Momodou Mustapha Fanneh , Technology Mo , Euclid University , University Of Applied Sciences , Gambia Technical Training Institution , Higher Education , Applied Sciences , Electrical Electronic , Mustapha Fanneh , Euclid Vice Chancellor , Van Puyenbroeck , Deputy Secretary General ,

Cyclists involved in hit-and-run crash in London

In serious pain, Randy Van Puyenbroeck had trouble sleeping. He was cycling with a group of members from the London Cycling Club on White Oak Road Sunday morning when he and a fellow rider were involved in a crash with a truck. ....

City Of , United Kingdom , Randy Van Puyenbroeck , Van Puyenbroeck , London Cycling Club , White Oak Road Sunday , Dodge Ram ,

Frontiers | The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there has long been evidence that the immune system is not completely incapable of responding to M. ulcerans infection. In particular, IL-1beta was recently shown to be present in BU lesions, and to be induced from M. ulcerans-exposed macrophages in a mycolactone-dependent manner. This has important implications for our understanding of BU, showing that mycolactone can act as the “second signal” for ....

United States , Western Australia , Le Bon , Scandj Rheumatol , Rheumatol Oxford , M Ulcerans Mycolactone Cytotoxicity , Pedrosaj Mycolactone , Waal Malefyt , Sarpong Duah , Rajko Reljic , Van Haver , Van Puyenbroeck , Thyet Mycolactone , Mycolactone Polyketide Synthases , Prof Pamela Small University Of Knoxville , Riverside Research Ethics Committee , Kennedy Institute Trustees , Wellcome Trust Investigator Award In Science , Streptomycin For Limited Buruli Ulcer Lesions , Prof Yoshito Kishi Harvard University , Lancet Glob Health , Dr Justice Boakye Appiah St George University London , West Africa , Immune Response , Buruli Ulcer , Wellcome Trust Investigator Award ,