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Muscular Dystrophy Association Celebrates FDA Approval of

New York, NY, Feb. 28, 2023 (GLOBE NEWSWIRE) The Muscular Dystrophy Association (MDA) celebrates the US Food and Drug Administration (FDA) approval of. ....

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Using motion capture technology and AI to monitor the progression of movement disorders

A multi-disciplinary team of researchers has developed a way to monitor the progression of movement disorders using motion capture technology and AI. ....

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Study explores cellular alterations in six distinct neurodegenerative diseases

A perplexing range of neurodegenerative diseases are known to attack distinct regions of the brain, causing severe cognitive and motor deficit. ....

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NEJM study: Hidden genetic anomaly behind common late-onset cerebellar ataxia

Researchers at the University of Miami Miller School of Medicine, McGill University and other institutions have found that a well-concealed genetic variation in the gene FGF14, called a DNA tandem repeat expansion, causes a common form of late-onset cerebellar ataxia, a brain disorder that interferes with coordinated movement. ....

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£1.6 million grant awarded to advance development of MND drug candidate

£1.6 million grant awarded to advance development of MND drug candidate
Researchers from the University of Sheffield s Institute for Translational Neuroscience (SITraN) have been awarded a £1.6 million grant from the Medical Research Council (MRC). The grant will support their partnership with Aclipse Therapeutics to advance the translational development of M102 - a drug candidate for the treatment of motor neuron disease (MND).
Neuroprotective properties of M102 were discovered by SITraN researchers in 2013. Preclinical models evidenced the potential for M102 to slow down MND progression, which affects a patient s ability to walk, talk, eat and breathe.
The drug candidate activates the NRF2 (nuclear factor erythroid 2-related factor 2) and HSF1 (Heat shock factor 1) signalling pathways, which can work in combination to protect motor neurons from injury. ....

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