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Cancer treatments may accelerate cellular aging


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New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue. The findings are published by Wiley early online in
CANCER, a peer-reviewed journal of the American Cancer Society.
Gene activity is often adjusted during life through epigenetic changes, or physical modifications to DNA that do not involve altering the underlying DNA sequence. Some individuals may experience epigenetic age acceleration (EAA) that puts them at a higher risk of age-related conditions than other individuals of the same chronological age. Investigators recently examined EAA changes during and following cancer treatment, and they looked for a potential link between these changes and fatigue in patients with head and neck cancer (HNC). ....

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