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Cancer treatments may accelerate cellular aging


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New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue. The findings are published by Wiley early online in
CANCER, a peer-reviewed journal of the American Cancer Society.
Gene activity is often adjusted during life through epigenetic changes, or physical modifications to DNA that do not involve altering the underlying DNA sequence. Some individuals may experience epigenetic age acceleration (EAA) that puts them at a higher risk of age-related conditions than other individuals of the same chronological age. Investigators recently examined EAA changes during and following cancer treatment, and they looked for a potential link between these changes and fatigue in patients with head and neck cancer (HNC). ....

United States , Deborahw Bruner , Jenniferc Felger , Nabilf Saba , Barbaraa Burtness , Hongyu Zhao , Jasmine Hoffman , Andrewh Miller , Cynthiae Chico , Evanthiac Wommack , J Michael Moore , Morgane Levine , Karenn Conneely , Dongm Shin , Jonathanj Beitler , Kristina Higgins , Canhua Xiao , Sangchoon Jeon , Kordm Kober , Emory University , Emory University School Of Nursing , American Cancer Society , American Cancer , Emory University School , Gang Peng , Published Online ,

The COVID-19 Pandemic as an Opportunity to Ensure a More Successful Future for Science and Public Health | Public Health | JAMA


Mark W. Tenforde, MD, PhD; Kiva A. Fisher, PhD, MPH; Manish M. Patel, MD, MSc
With the advent of the 21st century, science and technology were expected to be formidable forces that would hopefully improve population health and well-being.
1 Furthermore, these forces would drive a rapidly changing and interconnected world, with communities and nations worldwide sharing common rewards (eg, economic development, health, and welfare) and facing common risks (eg, pandemics, chronic noncommunicable diseases, environmental damage, nuclear weapons, climate change). In this context, effective governance and communications were to be cornerstones for delivering the promise of science and technology for enhancing public health. ....

United States , United Kingdom , Gregoryl Fenves , Reynaldo Martorell , Jamesm Hughes , Lindaa Mccauley , Deborahw Bruner , Robertf Breiman , Ruthl Berkelman , Godfreyp Oakley , Km Venkat Narayan , Michael Me Johns , Allani Levey , Markl Rosenberg , Mahlon Delong , Joelp Baumgart , Susans Margulies , Maxd Cooper , Waltera Orenstein , Denisej Jamieson , Raymondj Dingledine , Clairee Sterk , School Of Medicine , Emory University , Head Of Task , American Association For The Advancement Of Science ,