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Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis

Author summary Why was this study done? Drug resistance poses a major barrier to the effective treatment of tuberculosis, especially in Moldova and other post-Soviet states which have the highest levels of resistance in the world. Individuals with tuberculosis resistant to the key drug rifampicin face a worse prognosis, a longer and more expensive course of treatment, and more side effects than individuals with rifampicin-susceptible tuberculosis. Until recently, the standard of care for rifampicin-resistant tuberculosis (RR-TB) involved many drugs in combination, often given for 18 months or longer. The newer, 6-month “BPaLM” regimen is comprised of 4 drugs (bedaquiline, pretomanid, linezolid, and moxifloxacin) to which resistance levels are currently low, and while it was shown to be just as effective as the standard of care when health outcomes were measured at 72 weeks from treatment initiation, its effect on lifetime health outcomes, costs, and the acquisition of dru ....

United States , United Kingdom , South Africa , Jennifer Thorley , National Institute Of Allergy , Decision Science Methods Group At Erasmus University , Harvard University , Tb Partnership Global Drug Facility , Health Decision Science , Phd Program In Health , Creative Commons Attribution License , National Institute , Infectious Diseases , Global Drug Facility , Consumer Price Index , Moldovan Leu , Gross Domestic Product , Georgian Lei , Soviet Union , Like Moldova , Although South Africa , Phd Program , Health Policy , Decision Science Methods Group , Erasmus University , Drug Therapy ,

Randomised Control Trials: the technique that transformed TB treatment

Randomised Control Trials: the technique that transformed TB treatment
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United Kingdom , Kamala Nehru , Bradford Hill , Austin Bradford Hill , Alexander Fleming , Narendra Modi , Jawaharlal Nehru , Health Matters , British Medical Research Council , World Tuberculosis Day , Indian Prime Minister Narendra Modi , Photo Credit , Sir Alexander Fleming , Sir Austin Bradford , Bradford Hill Criteria , Multi Drug Tuberculosis , Extensively Drug Resistant Tuberculosis ,

Tuberculosis makes a comeback in the U.S. as cases rise

There were almost 10,000 documented cases of tuberculosis in the U.S. last year, the third straight year of increased cases ....

United States , World Health Organization , Centers For Disease , Disease Control , Mortality Weekly , Mycobacterium Tuberculosis , Latent Tuberculosis , Extensively Drug Resistant Tuberculosis , World Tuberculosis Day ,

'Large' TB outbreak may affect 800 people who were incarcerated in Washington

Health officials said a "large" TB outbreak in the Washington state prison system may have affected over 800 people who were incarcerated and later released. ....

District Of Columbia , United States , Department Of Health , Washington State Department Of Corrections , Pierce County Health Department , Tacoma Pierce County Health Department , Washington State Department , World Health Organization , Health Medical Pharma , Extensively Drug Resistant Tuberculosis , Health Professional , Tuberculosis Diagnosis ,

Washington state high school faces tuberculosis scare, evaluations recommended for 135 people

Roughly 135 people from a Washington state high school were recommended to be evaluated for tuberculosis after a school community member was diagnosed. ....

United States , Health Medical Pharma , Latent Tuberculosis , Tuberculosis Diagnosis , Extensively Drug Resistant Tuberculosis ,