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Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis

Author summary Why was this study done? Drug resistance poses a major barrier to the effective treatment of tuberculosis, especially in Moldova and other post-Soviet states which have the highest levels of resistance in the world. Individuals with tuberculosis resistant to the key drug rifampicin face a worse prognosis, a longer and more expensive course of treatment, and more side effects than individuals with rifampicin-susceptible tuberculosis. Until recently, the standard of care for rifampicin-resistant tuberculosis (RR-TB) involved many drugs in combination, often given for 18 months or longer. The newer, 6-month “BPaLM” regimen is comprised of 4 drugs (bedaquiline, pretomanid, linezolid, and moxifloxacin) to which resistance levels are currently low, and while it was shown to be just as effective as the standard of care when health outcomes were measured at 72 weeks from treatment initiation, its effect on lifetime health outcomes, costs, and the acquisition of dru ....

United States , United Kingdom , South Africa , Jennifer Thorley , National Institute Of Allergy , Decision Science Methods Group At Erasmus University , Harvard University , Tb Partnership Global Drug Facility , Health Decision Science , Phd Program In Health , Creative Commons Attribution License , National Institute , Infectious Diseases , Global Drug Facility , Consumer Price Index , Moldovan Leu , Gross Domestic Product , Georgian Lei , Soviet Union , Like Moldova , Although South Africa , Phd Program , Health Policy , Decision Science Methods Group , Erasmus University , Drug Therapy ,

Warnings About Moldova's EU Candidacy Everyone Should Heed

Although Moldovan President Maia Sandu has been regarded as the most pro-Western and EU-enthusiastic leader of the country promising to add a referendum on accession to the European Union to the upcoming presidential elections there are several warning signs regarding the government’s conduct that the European community, and indeed Moldovans, should heed. - writes Admir Lisica . Framing Moldova’s EU membership […] ....

Maia Sandu , Admir Lisica , European Commission , Office For Democratic Institutions , European Parliament , International Republican Institute , Corruption Prosecutor Office , Information Security Services , European Council , Moldova Commission For Exceptional Situations , European Union , Central Elections Commission , Freedom House , Venice Commission , Council Of Europe Congress , Although Moldovan President Maia Sandu , Exceptional Situations , International Republican , Democratic Institutions , Human Rights , Europe Congress , Regional Authorities , President Sandu , Anti Corruption Prosecutor , Common Market , Western European ,