Muthiah Vaduganathan, MD, MPH, offers perspective on data from the PARAGLIDE-HF trial as well as a pooled analysis of data from the PARAGLIDE-HF and PARAGON-HF trials.
The diagnosis of heart failure is usually missed, denying patients treatments that could improve wellbeing and reduce mortality. That’s the finding from a late breaking science presentation today at Heart Failure 2023, a scientific congress of the European Society of Cardiology (ESC). “For patients with heart failure, lifestyle advice, medicines and devices can improve symptoms, reduce morbidity and prolong life but this requires someone to recognise and diagnose the condition,” said principal investigator Professor John Cleland of the University of Glasgow, UK. “The earlier the diagnosis, the more effective treatment is likely to be. However, the results of this analysis suggest that most patients with heart failure die without the diagnosis ever being recognised.”
AstraZeneca’s Farxiga (dapagliflozin) has been approved in the US to reduce the risk of cardiovascular (CV) death, hospitalisation for heart failure (hHF) and urgent heart failure (HF) visits in adults with HF. The approval by the Food and Drug Administration (FDA) was based on positive results from the DELIVER .