Current HFA-ESC guidelines for diuretics in acute heart failure led to significant increases in natriuresis and diuresis over 2 days compared with usual care, in ENACT-HF.
The SGLT2 inhibitor didn t relieve congestion more effectively than a thiazide-like diuretic when added to furosemide in loop-diuretic–resistant patients with acute heart failure.
An electronic alert system didn t get physicians to prescribe more guideline-directed meds at discharge for their patients hospitalized with acute HF in a randomized trial.
The copper chelator trientine was well tolerated and lowered NT-proBNP levels in patients with heart failure and reduced ejection fraction in a phase 2 study.