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Scientists reveal how sensory protein changes shape with nanometer resolution

Scientists reveal how sensory protein changes shape with nanometer resolution
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Ardem Patapoutian , Eric Mulhall , Scott Henderson , Dorris Neuroscience Center At Scripps Research , Scripps Research , Scripps Research Core Microscopy Facility , Howard Hughes Medical Institute , Department Of Integrative Structural , Dorris Neuroscience Center , Integrative Structural , Howard Hughes Medical ,

Hearing acrobatics


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The sense of hearing is, quite literally, a molecular tightrope act. Turns out, it involves acrobatics as well.
In a paper published in
Nature Communications on Feb 8, researchers at Harvard Medical School and Boston Children s Hospital show that a dynamic and delicate connection between two pairs of diminutive protein filaments plays a central role in in hearing.
The tension held by these filaments, together called a tip link, is essential for the activation of sensory cells in the inner ear. The team s analyses reveal that the filaments, which are joined end-to-end, work together like trapeze artists holding hands. Their grasp on each other can be disrupted, by a loud noise, for example. But with a two-handed grip, they can quickly reconnect when one hand slips. ....

United States , David Corey , Mounir Koussa , Eric Mulhall , Andrew Ward , Darren Yang , Wesley Wong , National Institutes Of Health , Harvard Medical School , Nature Communications On Feb , Blavatnik Institute , Nature Communications , Boston Children , Bertarelli Professor , Translational Medical Science , Wyss Institute , Biologically Inspired Engineering , National Institutes , Cell Biology , Molecular Biology , Hearing Speech , ஒன்றுபட்டது மாநிலங்களில் , டேவிட் கோரி , எரிக் முல்ஹால் , ஆண்ட்ரூ வார்டு , டேரன் யாங் ,