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Nanofibrous mats for topical delivery


S. aureus ATCC25923, respectively. Meanwhile, a slightly lower activity against
P. aeruginosa ATCC27853 (11.1 and 13.2 mm) was demonstrated by CF3 and CF4, respectively. MRSA (
S. aureus ATCC43300), showed moderate resistance where CF3 and CF4 exhibited 11.7 mm and 13.5 mm inhibition zones, respectively.
Such findings indicate that the hybrid NPs are responsible for the antibacterial activity of the composite fibers. The NPs are released steadily over 48-h incubation period, and exhibit zones of inhibition against the three selected bacterial strains. It can be noted that the Gram-negative
P. aeruginosa showed higher resistance than
S. aureus and MRSA. This might be attributed to the intrinsic difference in their cell wall structure. The Gram-negative bacterial cell wall is thick, hence acting as a strong biological barrier against biocides. It consists of lipids, proteins and lipopolysaccharides (LPS). However, the thinner and loose Gram-positive bacterial ....

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Fully 3D-printed soft robots with integrated fluidic circuitry


Abstract
The emergence of soft robots has presented new challenges associated with controlling the underlying fluidics of such systems. Here, we introduce a strategy for additively manufacturing unified soft robots comprising fully integrated fluidic circuitry in a single print run via PolyJet three-dimensional (3D) printing. We explore the efficacy of this approach for soft robots designed to leverage novel 3D fluidic circuit elements e.g., fluidic diodes, “normally closed” transistors, and “normally open” transistors with geometrically tunable pressure-gain functionalities to operate in response to fluidic analogs of conventional electronic signals, including constant-flow [“direct current (DC)”], “alternating current (AC)”–inspired, and preprogrammed aperiodic (“variable current”) input conditions. By enabling fully integrated soft robotic entities (composed of soft actuators, fluidic circuitry, and body features) to be rapidly disseminated, modified o ....

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