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Time-resolved chemical monitoring of whole plant roots with printed electrochemical sensors and machine learning

Time-resolved chemical monitoring of whole plant roots with printed electrochemical sensors and machine learning
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United Kingdom , City Of , Tamil Nadu , United Kingdom General , Marie Sklodowska Curie , Gro Evergreen Garden Care United Kingdom Ltd , Melinda Gates Foundation Grand Challenges Explorations , Turkish Ministry Of Education , Us Army , Gwent Group , Agri Futures Lab , European Union Horizon , Imperial College Centre For Processable Electronics , Office Depot , Imperial College London , Xerox Colorqube , Black Madras , Extreme Gradient Boosting , Supplementary Text , Chiltern Seeds , Kings Seeds , Evergreen Garden Care United Kingdom Ltd , Humidity Pressure Sensor , Arduino Due , Hanna Instruments , Imperial College Centre ,

Motion of VAPB molecules reveals ER–mitochondria contact site subdomains

To coordinate cellular physiology, eukaryotic cells rely on the rapid exchange of molecules at specialized organelle–organelle contact sites1,2. Endoplasmic reticulum–mitochondrial contact sites (ERMCSs) are particularly vital communication hubs, playing key roles in the exchange of signalling molecules, lipids and metabolites3,4. ERMCSs are maintained by interactions between complementary tethering molecules on the surface of each organelle5,6. However, due to the extreme sensitivity of these membrane interfaces to experimental perturbation7,8, a clear understanding of their nanoscale organization and regulation is still lacking. Here we combine three-dimensional electron microscopy with high-speed molecular tracking of a model organelle tether, Vesicle-associated membrane protein (VAMP)-associated protein B (VAPB), to map the structure and diffusion landscape of ERMCSs. We uncovered dynamic subdomains within VAPB contact sites that correlate with ER membrane curvature and ....

Supplementary Text , Extended Data , Supplementary Video ,

A female woolly mammoth's lifetime movements end in an ancient Alaskan hunter-gatherer camp

A female woolly mammoth's lifetime movements end in an ancient Alaskan hunter-gatherer camp
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United States , Brooks Range , Tanana River , Shaw Creek , Healy Lake , White Mountains , Deutsche Forschungsgemeinschaft , Monte Carlo , Little John , Pee Dee , German Research Foundation , Healy Lake Village Council , Us National Park Service , Mj Murdock Charitable , National Park Service , Mcmaster University , Alaska Quaternary Center , National Science Foundation , Last Glacial Maximum , Supplementary Text , Swan Point , Cultural Zone , Broken Mammoth , Supplemental Materials , Eastern Beringia , Vienna Pee Dee ,

Moderated ionic bonding for water-free recyclable polyelectrolyte complex materials

Moderated ionic bonding for water-free recyclable polyelectrolyte complex materials
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Supplementary Text ,

Spatiotemporal-social association predicts immunological similarity in rewilded mice

Spatiotemporal-social association predicts immunological similarity in rewilded mice
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Supplementary Text ,