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Move over, Humira, there's a new mega-blockbuster in town

There was a time not that long ago when Merck & Co. Inc.’s Keytruda (pembrolizumab), with its multiple cancer indications, was seen as the heir apparent to Humira’s title of the biggest blockbuster drug. Not anymore. That title now belongs to Novo Nordisk A/S’ semaglutide, approved as Ozempic in 2017 to treat diabetes and as Wegovy in 2021 to help with weight loss. ....

Novo Nordisk , Merck Co , Novo Nordiska S , Merck Amp Co Inc , Abbvie Inc , Eli Lilly And Co , Teva Pharmaceutical Industries Ltd , Gilead Sciences Inc , Drug Prices , Analysis And Data Insight , Endocrine Metabolic ,

Vertex buying Alpine for $4.9B for phase III-ready IgAN asset

Vertex Pharmaceuticals Inc. is acquiring Alpine Immune Sciences Inc. for $4.9 billion in cash to gain Alpine’s lead product, phase III-ready povetacicept, which demonstrates best-in-class potential in patients with immunoglobulin A nephropathy (IgAN). ....

Reshma Kewalramani , Vertex Pharmaceuticals Inc , Alpine Immune Sciences Inc , Vertex Pharmaceuticals , Alpine Immune Sciences , Alpine Immune Sciences Inc , Vertex Pharmaceuticals Inc , Kidney Disease , Immunoglobulina Nephropathy , Immunoglobulin A , Deals Andm Amp A , Endocrine Metabolic , Genitourinary Sexual Function ,

Australian scientists explore MERTK as a target against organ fibrosis

A small molecule could provide a new therapeutic approach against organ fibrosis. Using genome-wide association (GWA) assays, a group of researchers of the Westmead Institute for Medical Research in Sydney identified Mer tyrosine kinase (MERTK) as a candidate to study fibrosis and showed that its inhibition with the experimental compound reduced this condition in mouse models’ liver, kidneys and lungs. ....

New South Wales , Mohammed Eslam , Westmead Institute For Medical Research , Westmead Institute , Medical Research , Bioworld Science , Endocrine Metabolic , Idiopathic Pulmonary Fibrosis , Liver Fibrosis , Kidney Fibrosis , Unc 569 ,

Me-two drug? Viking mid-stage trial wins with GLP-1/GIP bid

The enticing prospect – and proven worth – of dually agonizing the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors gained more evidence in a big way from Viking Therapeutics Inc. with VK-2735 in a phase II weight loss study. Shares of San Diego-based Viking Therapeutics Inc. (NASDAQ:VKTX) closed Feb. 27 at $85.05, up $46.57, or 121%, as investors learned that the drug achieved the primary and all secondary endpoints in the phase II study called Venture, with significant body-weight drops at all doses compared to placebo. ....

San Viking Therapeutics Inc , Therapeutics Inc , Viking Therapeutics , San Diego Based Viking Therapeutics , Viking Therapeutics Inc , Vk 2735 , Glp 1 , Endocrine Metabolic , Glucagon Like Peptide 1 , Glucose Dependent Insulinotropic Polypeptide Receptors ,

Immunoglobulin G antibody acts as a metabolic aging factor

Immunoglobulin G (IgG), an antibody that participates in the response to infection, could have a specific role in metabolism. During aging, it accumulates in certain tissues inducing metabolic dysfunction and fibrosis of fat tissue. This effect could be prevented through an intracellular receptor that contributes to the delivery of IgG. A team of researchers from Columbia University and Peking University (PKU) demonstrated that reducing excess IgG improved the metabolic health of aged mice and increased their life expectancy. ....

Columbia University , Peking University , Bioworld Science , Metabolic Dysfunction , Endocrine Metabolic , Drug Design , Rug Delivery And Technologies ,