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The first generation of COVID-19 vaccines has been very effective; however, they do have certain limits. Their effectiveness can diminish without a booster shot, and they may be less effective against certain variants. ....
DNA vaccine protects non-human primates against MERS, study shows SHARES A candidate vaccine has shown potential against MERS in non-human primates, when administered intradermally. A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute, US, induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunisation regimen. “While several vaccine products are being advanced against MERS and other coronaviruses, low-dose delivery and shortened regimes are crucial to rapidly induce protective immunity, particularly during emerging outbreaks, as the current SARS-CoV-2 pandemic has emphasised,” said Dr David Weiner, who led the study. ....