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Stimulating Immune System to Fight Cancer

Max Planck scientists from Dortmund find immunoregulatory substances with newly developed test system
Cancer cells have evolved mechanisms to escape the body’s immune defense. Agents that prevent immune escape are attractive targets for the development of new cancer therapies. A group of scientists led by Herbert Waldmann and Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund has now developed a new cell-based test system to identify immunoregulatory modulators. Screening a library of over 150,000 substances revealed several potent substances with unprecedented structure.
384-well plate for the detection of potential Inhibitors.
© MPI of Molecular Physiology
Our immune system is very successful when it comes to warding off viruses and bacteria. It also recognizes cancer cells as potential enemies and fights them. However, cancer cells have developed strategies to evade surveillance by the immune system and to preven ....

Slava Ziegler , Herbert Waldmann , Max Planck , Elisabeth Hennes , Max Planck Institute , Molecular Physiology , Different Mechanisms , Max Planck Society , Immune Response , Clinical Trials , ஹெர்பர்ட் வால்ட்மேன் , மூலக்கூறு உடலியல் , நோய் எதிர்ப்பு சக்தி பதில் , மருத்துவ சோதனைகள் ,

Stimulating the immune system to fight cancer

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IMAGE: Elisabeth Hennes is searching for potential IDO1 inhibitors with the nerwly developed cell-based assay.
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Credit: @MPI of Molecular Physiology
Our immune system is very successful when it comes to warding off viruses and bacteria. It also recognizes cancer cells as potential enemies and fights them. However, cancer cells have developed strategies to evade surveillance by the immune system and to prevent immune response.
In recent years, fighting cancer with the help of the immune system has entered into clinical practice and gained increasing importance as a therapeutical approach. Current therapies apply so-called immune checkpoint inhibitors. Immune checkpoints are located on the surface of cancer cells and slow down the immune response. Targeting these checkpoints can release this tumour-induced brake. Another strategy developed by cancer cells to escape the immune response is the production of the enzyme indoleamine-2,3-dio ....

Slava Ziegler , Elisabeth Hennes , Herbert Waldmann , Different Mechanisms , Cell Biology , Molecular Biology , Pharmaceutical Sciences , ஹெர்பர்ட் வால்ட்மேன் , உயிர் வேதியியல் , செல் உயிரியல் , மூலக்கூறு உயிரியல் , மருந்து அறிவியல் ,