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Newly discovered bacterial communication system aids antimicrobial resistance

Researchers discovered a stress signaling system that enables bacteria to adapt and protect themselves against the immune system and certain antibiotics. The discovery of RlmN as a stress sensor reveals a new mechanism of antimicrobial resistance that can be targeted for drug development. ....

Peter Dedon , Lee Wei Lin , Alliance For Research , Nanyang Technological University Singapore , Singapore Center , Nature Communications , National Research Foundation , Environmental Life Sciences Engineering , Campus For Research Excellence And Technological Enterprise , Antimicrobial Resistance , Nanyang Technological University , Research Excellence And Technological Enterprise , Mit Smart , Smart Amr , Ingapore Mit Alliance For Research And Technology , Antimicrobial Resistance Amr , Edon Laboratory , Peter Dedon , Eactive Oxygen Species Ros , Drug Resistance , Drug Development , Antibiotic Resistant Bacteria , Nterococcus Faecalise Faecalis , Tress Signalling , Lee Wei Lin ,

"Invited review: Thermal effects on oxidative stress in vertebrate ecto" by Daniel J. Ritchie and Christopher R. Friesen

Human-induced climate change is occurring rapidly. Ectothermic organisms are particularly vulnerable to these temperature changes due to their reliance on environmental temperature. The extent of ectothermic thermal adaptation and plasticity in the literature is well documented; however, the role of oxidative stress in these processes needs more attention. Oxidative stress occurs when reactive oxygen species, generated mainly through aerobic respiration, overwhelm antioxidant defences and damage crucial biomolecules. The effects of oxidative damage include the alteration of life-history traits and reductions in whole-organism fitness. Here we review the literature addressing experimental temperature effects on oxidative stress in vertebrate ectotherms. Acute and acclimation temperature treatments produce distinctly different results and highlight the role of phylogeny and thermal adaptation in shaping oxidative stress responses. Acute treatments on organisms adapted to stable environme ....

Life History , Oxidative Damage , Eactive Oxygen Species Ros , Thermal Performance ,