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6 Some studies revealed that lncRNAs are related to the development and progression of DN. 7–9 For example, lncRNA MALAT1 can regulate renal tubular epithelial pyroptosis by modulating miR-23c targeting of ELAVL1 in DN. 10 LncRNA Tug1 can regulate mitochondrial bioenergetics in DN. 3 Moreover, lncRNA PVT1 (PVT1) has been shown to be involved in accelerating the progression of DN by promoting ECM accumulation and increasing expression of fibronectin 1 (FN1). 11 However, the underlying mechanism of PVT1 on diabetic nephropathy remains unclear. MicroRNAs (miRNAs) are non-coding RNAs with 20–30 nucleotides that can bind to mRNA to regulate its protein expression. 12 Previous reports indicated that miRNA-325-3p can suppress inflammation and fibrosis in the progression of DN. ....