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Study could serve as guidepost for developing new therapies for Alzheimer s disease In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta the neurotoxin believed to be at the root of Alzheimer s disease (AD) forms in axons and related structures that connect neurons in the brain, where it causes the most damage. Their findings, published in Cell Reports, could serve as a guidepost for developing new therapies to prevent the onset of this devastating neurological disease. Among his many contributions to research on AD, Rudolph Tanzi, PhD, vice chair of Neurology and co-director of the McCance Center for Brain Health at MGH, led a team in 1986 that discovered the first Alzheimer s disease gene, known as APP, which provides instructions for making amyloid protein precursor (APP). ....
E-Mail BOSTON - In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta the neurotoxin believed to be at the root of Alzheimer s disease (AD) forms in axons and related structures that connect neurons in the brain, where it causes the most damage. Their findings, published in Cell Reports, could serve as a guidepost for developing new therapies to prevent the onset of this devastating neurological disease. Among his many contributions to research on AD, Rudolph Tanzi, PhD, vice chair of Neurology and co-director of the McCance Center for Brain Health at MGH, led a team in 1986 that discovered the first Alzheimer s disease gene, known as APP, which provides instructions for making amyloid protein precursor (APP). When this protein is cut (or cleaved) by enzymes first, beta secretase, followed by gamma secretase the byproduct is amyloid beta (sometimes shortened to Abeta). Large deposits of amyloid beta are believ ....
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