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Study solves mystery of how amyloid beta forms in brain nerve cells


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BOSTON - In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta the neurotoxin believed to be at the root of Alzheimer s disease (AD) forms in axons and related structures that connect neurons in the brain, where it causes the most damage. Their findings, published in
Cell Reports, could serve as a guidepost for developing new therapies to prevent the onset of this devastating neurological disease.
Among his many contributions to research on AD, Rudolph Tanzi, PhD, vice chair of Neurology and co-director of the McCance Center for Brain Health at MGH, led a team in 1986 that discovered the first Alzheimer s disease gene, known as APP, which provides instructions for making amyloid protein precursor (APP). When this protein is cut (or cleaved) by enzymes first, beta secretase, followed by gamma secretase the byproduct is amyloid beta (sometimes shortened to Abeta). Large deposits of amyloid beta are believ ....

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ProMIS Neurosciences Inc.: ProMIS Neurosciences appoints renowned neuroscientist, Dr. Rudolph Tanzi, as Chair of Scientific Advisory Board


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TORONTO and CAMBRIDGE, Mass., May 12, 2021 (GLOBE NEWSWIRE) ProMIS Neurosciences, Inc. (TSX: PMN); (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics selectively targeting toxic oligomers implicated in the development of neurodegenerative diseases, today announced the appointment of Rudolph Tanzi, Ph.D, as Chair of the Company s scientific advisory board (SAB). Dr. Tanzi is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University and Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-Director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital. ....

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