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New, precise, and efficient DNA sequencing method may lead to easier testing and earlier cancer detection

The technique, created by Penn Medicine researchers, requires smaller DNA samples for testing and opens up potential new opportunities for next-generation diagnostics. ....

Rahul Kohli , Perelman School Of Medicine , Perelman School , Direct Methylation Sequencing , Nature Chemical Biology , Penn Medicine , Tong Wang ,

New, precise, and efficient DNA sequencing method may lead to easier testing and earlier cancer detection

Researchers from the Perelman School of Medicine at the University of Pennsylvania have invented a new way to map specific DNA markings called 5-methylcytosine (5mC) which regulate gene expression and have key roles in health and disease. The innovative technique allows for scientists to profile DNA using very small samples and without damaging the sample which means it can potentially be used in liquid biopsies (testing for cancer markers in the bloodstream) and early cancer detection. ....

Rahul Kohli , Perelman School Of Medicine , University Of Pennsylvania , Nature Chemical Biology , Perelman School , Direct Methylation Sequencing , Penn Medicine , Tong Wang ,