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Frontiers | The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there has long been evidence that the immune system is not completely incapable of responding to M. ulcerans infection. In particular, IL-1beta was recently shown to be present in BU lesions, and to be induced from M. ulcerans-exposed macrophages in a mycolactone-dependent manner. This has important implications for our understanding of BU, showing that mycolactone can act as the “second signal” for ....

United States , Western Australia , Le Bon , Scandj Rheumatol , Rheumatol Oxford , M Ulcerans Mycolactone Cytotoxicity , Pedrosaj Mycolactone , Waal Malefyt , Sarpong Duah , Rajko Reljic , Van Haver , Van Puyenbroeck , Thyet Mycolactone , Mycolactone Polyketide Synthases , Prof Pamela Small University Of Knoxville , Riverside Research Ethics Committee , Kennedy Institute Trustees , Wellcome Trust Investigator Award In Science , Streptomycin For Limited Buruli Ulcer Lesions , Prof Yoshito Kishi Harvard University , Lancet Glob Health , Dr Justice Boakye Appiah St George University London , West Africa , Immune Response , Buruli Ulcer , Wellcome Trust Investigator Award ,

microRNAs als mögliche Biomarker zur Früherkennung von Krankheiten wie Parkinson

microRNAs als mögliche Biomarker zur Früherkennung von Krankheiten wie Parkinson Bei frühzeitiger Diagnose könnten die im Körper ablaufenden Kettenreaktionen verlangsamt werden Rüdiger Koop / Universität des Saarlandes Die Humangenetikerin Caroline Diener forscht im Team von Professor Eckart Meese am Institut für Humangenetik der Universität des Saarlandes. Hineinzoomen ).addClass( image-details ); var $imageCaption = $( ).addClass( image-caption ).text(caption); $imageDetails.append($imageCaption); element = $( ).append( × ).append($imageHolder).append($imageDetails)[0]; img.draggable = false; if (title) { element.title = title; } if (altText) { element.alt = altText; } $(img).on( load error , callbackWra ....

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microRNAs als Biomarker zur Früherkennung von neurodegenerativen Erkrankungen

microRNAs als Biomarker zur Früherkennung von neurodegenerativen Erkrankungen
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