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In 2016, Peter Kim, PhD, was drawn to a presentation given by Dehua Pei, PhD, showcasing data on a novel class of peptides developed at the Ohio State University. In his new role as an advisor at 5AM Ventures, Kim was looking into the use of peptides in medicine. Pei then co-founded Entrada Therapeutics and raised $59 million in a Series A financing co-led by 5AM Ventures. ....
For decades, scientists have wondered how large molecules such as proteins pass through cell walls, also known as plasma membranes, without leaving a ....
Nanobodies may be the key to blocking tick-borne bacterial infection Tiny molecules called nanobodies, which can be designed to mimic antibody structures and functions, may be the key to blocking a tick-borne bacterial infection that remains out of reach of almost all antibiotics, new research suggests. The infection is called human monocytic ehrlichiosis, and is one of the most prevalent and potentially life-threatening tick-borne diseases in the United States. The disease initially causes flu-like symptoms common to many illnesses, and in rare cases can be fatal if left untreated. Most antibiotics can t build up in high enough concentrations to kill the infection-causing bacteria, Ehrlichia chaffeensis, because the microbes live in and multiply inside human immune cells. Commonly known bacterial pathogens like Streptococcus and E. coli do their infectious damage outside of hosts cells. ....
Using nanobodies to block a tick-borne bacterial infection Tiny molecules called nanobodies, which can be designed to mimic antibody structures and functions, may be the key to blocking a tick-borne bacterial infection that remains out of reach of almost all antibiotics, new research suggests. The infection is called human monocytic ehrlichiosis, and is one of the most prevalent and potentially life-threatening tick-borne diseases in the United States. The disease initially causes flu-like symptoms common to many illnesses, and in rare cases can be fatal if left untreated. Most antibiotics can’t build up in high enough concentrations to kill the infection-causing bacteria, ....