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Exclusive - A New Strategy for Immunotherapy of Cancer

Exclusive - A New Strategy for Immunotherapy of Cancer
isracast.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from isracast.com Daily Mail and Mail on Sunday newspapers.

Hebrew University , Israel General , Slavins Allogeneic , Lewis Thomas , Richmond Prehn , Michael Har Noy , Macfarlane Burnet , Epstein Barr , Medicinab Aires , Hebrew University Medical Center , Department Of Bone Marrow Transplantation , Quality Medical Publishing Inc , Immunovative Therapies Ltd , Sir Macfarlane Burnet , Bone Marrow Transplantation , Hadassah Hebrew University Medical Center , Immunovative Therapies , Transl Med , Leuk Res , Percutaneous Prostate , Quality Medical Publishing , Anti Tumor Effect , Allogeneic Bone , Stem Cell Transplant Without Graft , Disease Toxicity , Matched Donor ,

p53 governs an AT1 differentiation programme in lung cancer suppression

Lung cancer is the leading cause of cancer deaths worldwide1. Mutations in the tumour suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis1–4, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, specifically by promoting alveolar type 1 (AT1) differentiation. Using mice that express oncogenic Kras and null, wild-type or hypermorphic Trp53 alleles in alveolar type 2 (AT2) cells, we observed graded effects of p53 on LUAD initiation and progression. RNA sequencing and ATAC sequencing of LUAD cells uncovered a p53-induced AT1 differentiation programme during tumour suppression in vivo through direct DNA binding, chromatin remodelling and induction of genes characteristic of AT1 cells. Single-cell transcriptomics analyses revealed that during LUAD evolution, p53 promotes AT1 differentiation through action in a transitional cell state analogo ....

United States , South Korea , Bj Sanchez Alvarado , Kenzelmann Broz , American Thoracic Society , Cancer Genome Atlas Research Network , Biomarkers Prev , Single Cell Wnt , Stem Cell , Cell Biol , Death Differ , Molecular Signatures Database , Sanchez Alvarado , Cell Rep , Cancer Biol , Acids Res , Peak Annotation ,

Post-Doctoral Position job with Rutgers, The State Univ RBHS

Post-Doctoral Position in Part time, Postdoctoral, Biomedicine with Rutgers, The State Univ RBHS. Apply Today. ....

New York , United States , Nature Communications , Chu Lab , Rutgers Cancer Institute Of New Jersey , Rutgers Cancer Institute , Death Differ , New Jersey , New Brunswick , Nature Careers , Ob Search ,

Frontiers | Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3

Frontiers | Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3
frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.

South Korea , United States , Chunhong Yan , Addgene Watertown , Manis Pregnane , Chadeek Ppargamma , Biochim Biophys Acta , Ubiquitin Ligases , Santa Clara , Abcam Cambridge , Trizol Invitrogen , Proteinone Rockville , Gastroenterol Hepatol , Tsonwin Hai , Shabekn Ubiquitin Ligases , Millipore Billerica , Nuclear Receptors , Dharmacon Thermo Fisher Scientific Inc , Governs The Receptor Association With Mitotic Chromatin , Graphpad Software Inc , Prism Software , Nuclear Localization Signal Region In Receptor , Dna Synthesis Kit Thermo Fisher Scientific Inc , Nuclear Receptor , Mechanisms Of Energy , Tsonwin Hai Ohio State University ,

COVID-19 targets human adrenal glands

COVID-19 targets human adrenal glands
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

Deutsche Forschungsgemeinschaft , Maria Schuster , Linda Friedrich , Elsevier Ltd , Diabetes Endocrinol , Death Differ , Mixed Lineage Kinase Domain Like Pseudokinase , Uta Lehnert , Adult Respiratory Distress Syndrome ,