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Phases of Pathophysiology of Chronic GVHD

The expert panel explores the immunological aspects of chronic GVHD, highlighting challenges in simultaneous management, addressing fibrosis, and emphasizing the importance of early intervention in evolving transplant care practices. ....

Dana Farber Cancer Institute , United States , Mitchell Horwitz , Corey Cutler , Hannah Choe , Bin Chen , Professor Of Medicine At Harvard Medical School , Ohio State University , Cell Therapy Program At Massachusetts , Marrow Transplant Program At Duke University , Cell Therapy Program , Massachusetts General Hospital , Harvard Medical School , Stem Cell Transplant Program , Adult Blood , Marrow Transplant Program , Duke University , Assistant Professor , Ohio State , Yi Bin Chen , Chronic Graft Versus Host Disease , Treatment Phases , Inflammatory Pathways In Gvhd , Lacrimal Gland , Early Intervention In Gvhd , Transplant Care Collaboration ,

Acute Versus Chronic Graft-Versus-Host Disease (GVHD)

Drs Yi-Bin Chen, Corey Cutler, Hannah Choe, and Mitchell Horwitz distinguish acute from chronic graft-versus-host disease (GVHD), how such distinction has changed over the last decades, and provide an overview of consensus definitions for disease grading. ....

Dana Farber Cancer Institute , United States , Mitchell Horwitz , Corey Cutler , Hannah Choe , Bin Chen , Marrow Transplant Program At Duke University , Ohio State University , Professor Of Medicine At Harvard Medical School , Cell Therapy Program At Massachusetts , Cell Therapy Program , Massachusetts General Hospital , Harvard Medical School , Stem Cell Transplant Program , Adult Blood , Marrow Transplant Program , Duke University , Assistant Professor , Ohio State , Chronic Graft Versus Host Disease , Acute Cgvhd , Pleomorphic Presentation , Grading Of Gvhd , Nih Consensus Criteria For Gvhd , Comprehensive Grading Of Cgvhd , Tissue Manifestation ,

Obinutuzumab Use Decreases Incidence of Steroid-Requiring cGVHD After Transplant

Utilizing obinutuzumab to enhance B-cell depletion significantly reduced the need for corticosteroids and increased relapse-free survival in patients with steroid-requiring chronic graft-vs-host disease undergoing well-matched hematopoietic stem cell transplant. ....

Dana Farber Cancer Institute , United States , Corey Cutler , Stanford University , National Institute Of Health , Fritz Laboratory , National Institute , B Cell Depletion , Chronic Graft Vs Host Disease , Hematopoietic Stem Cell Transplant , Phase 2 Study Nct02867384 , 2023 Ash Annual Meeting ,

B-Cell Depletion With Obinutuzumab May Prevent GVHD

Researchers determined obinutuzumab administered after HSCT resulting in B-cell depletion was associated with lower rates of chronic GVHD. ....

Dana Farber Cancer Institute , United States , Corey Cutler ,

Cimeio Therapeutics Presents Data for its CD45 Universal Heme ADC at ASH

Cimeio Therapeutics Presents Data for its CD45 Universal Heme ADC at ASH
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United States , San Diego , Corey Cutler , Steve Edelson , Stefan Klotter , American Society Of Hematology , Cimeio Therapeutics Inc , Stem Cell Transplantation Program , Hspcs Are Shielded From , Professor Of Medicine At Harvard Medical School , Dana Farber Cancer Institute , American Society , Stem Cells Expressing Engineered , Near Universal Targeted Therapy , Hematologic Diseases , Are Shielded From , Medical Director , Harvard Medical , Cimeio Therapeutics , Lassen Sie ,