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Secret genetic switch in zebrafish key to heart regeneration


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Secret genetic switch in zebrafish key to heart regeneration
Scientists have discovered a critical new gene in zebrafish that helps them repair damaged heart muscle.
Researchers at the Victor Chang Cardiac Research Institute (VCCRI) and UNSW Sydney have identified a genetic switch in zebrafish that turns on cells, allowing them to divide and multiply after a heart attack and resulting in the complete regeneration and healing of damaged heart muscle in these fish.
It’s already known that zebrafish can heal their own hearts, but how they performed this incredible feat remained unknown until now. In research published this month in Science, the team drilled down into a critical gene known as Klf1 that previously had only been identified in red blood cells. For the first time they discovered it played a vital role in healing damaged hearts. ....

New South Wales , Bob Graham , Ozren Bogdanovic , Kazu Kikuchi , Daniel Hesselson , David Humphreys , Victor Chang Cardiac Research Institute , Biophysics Division , Garvan Institute Of Medical Research , Head Of The Institute Molecular Cardiology , Senior Lecturer , Molecular Cardiology , Garvan Institute , Medical Research , Conjoint Senior Lecturer Dr Kazu Kikuchi , Associate Professor Ozren Bogdanovic , Adjunct Lecturer Daniel Hesselson , Conjoint Lecturer David , University Of New South Wales , Unsw Sydney , Heart Regeneration , Drug Development , Heart Disease , Heart Attack , புதியது தெற்கு வேல்ஸ் , பாப் கிரஹாம் ,