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Tingting Geng and colleagues investigate whether lifestyle behaviours could affect microvascular complications among patients with type 2 diabetes in the UK Biobank.
l-carnitine is emerging as an item of interest for cardiovascular disease (CVD) prevention and treatment, but controversy exists. To examine the effectiveness and safety of l-carnitine, we assessed how genetically different levels of l-carnitine are associated with CVD risk and its risk factors. Given higher CVD incidence and l-carnitine in men, we also examined sex-specific associations. We used Mendelian randomization to obtain unconfounded estimates. Specifically, we used genetic variants to predict l-carnitine, and obtained their associations with coronary artery disease (CAD), ischemic stroke, heart failure, and atrial fibrillation, as well as CVD risk factors (type 2 diabetes, glucose, HbA1c, insulin, lipid profile, blood pressure and body mass index) in large consortia and established cohorts, as well as sex-specific association in the UK Biobank. We obtained the Wald estimates (genetic association with CVD and its risk factors divided by the genetic association with l-carnitine
In an observational study, Tingting Geng and colleagues investigate associations between serum vitamin D and dementia risk among individuals with Type 2 diabetes in the UK Biobank.
Research Article
Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study
Rema Ramakrishnan, Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing
Affiliations Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom, University of New South Wales, Sydney, Australia Roles Investigation, Methodology, Resources, Validation, Writing – review & editing
Affiliations Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom, National Institute of Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS F