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Whole Genome Sequencing for AML/MDS Risk Stratification

Two clinical trials for AML or MDS are open and enrolling at Siteman Cancer Center and Washington University School of Medicine in St. Louis. ....

David Spencer , Meagan Jacoby , Siteman Cancer Center At Barnes , Mcdonnell Genome Institute At Wash , Washington University School Of Medicine , Centers For Medicare Medicaid Services , Washington University Pathology Services , Siteman Cancer Center , Barnes Jewish Hospital , Washington University School , New England Journal , Clinical Sequencing Facility , Mcdonnell Genome Institute , Chromoseq Testing ,

Whole genome sequencing may guide blood cancer treatment

Whole genome sequencing may guide blood cancer treatment
For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes.
Some of these tests rely on technology that was invented more than 60 years ago and has been used clinically for the past three decades.
Now, a new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing. In addition, results can be returned to patients in just a few days, making whole genome sequencing a potentially viable approach for determining the best treatment regimen for a parti ....

Ericj Duncavage , Mollyc Schroeder , Peter Campbell , Davidh Spencer , Emily Henderson , Mcdonnell Genome Institute , Washington University , Siteman Cancer Center At Barnes , Wellcome Sanger Institute In Cambridge , Washington University School Of Medicine , Siteman Cancer Center , Department Of Pathology Immunology , Washington University School , New England Journal , Study Senior Author , Assistant Professor , Medical Director , Clinical Sequencing Facility , Mcdonnell Genome , Barnes Jewish Hospital , Siteman Cancer , Wellcome Sanger Institute , Blood Cancer , Whole Genome Sequencing , Acute Myeloid Leukemia , Bone Marrow ,