Live Breaking News & Updates on Clin Transl Sci|Page 1

Stay updated with breaking news from Clin transl sci. Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.

Shifting the Balance from Animals to New Approach Methods: We're Working Toward It!

Shifting the Balance from Animals to New Approach Methods: We're Working Toward It!
plos.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from plos.org Daily Mail and Mail on Sunday newspapers.

United States , Barbara Lf Kaplan , Freie Universitat , Barbara Kaplan , William Slikker Jr , Environmental Health Sciences , Department Of Comparative Biomedical Sciences , Perinatal Research Program , Animal Health , Toxicological Research , University Of California At Davis , Altern Lab Anim , Scientific Liaison Coalition , National Cancer Institute , Michigan State University , National Center , William Slikker , Diabetes Res Clin Pract , Protecting Human , Road From Animal Models , New Approach , Pharmacol Rev , Cancer Institute , Helping Dogs , Exp Biol Med , Clin Transl Sci ,

Frontiers | Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection

1 Abstract The devastating Ebola outbreak in West Africa in 2013-2016 accelerated the progress of several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several IPs were used during that outbreak, but no conclusion on efficacy could be drawn. Only the Randomized Controlled Trial (RCT) on ZMapp was promising but inconclusive. More recently, during the second largest Ebola outbreak in North Kivu and Ituri provinces, Democratic Republic of the Congo (DRC), four IPs (Remdesivir, Regeneron, ZMapp and MAb114) have been evaluated in a RCT, the Pamoja Tulinde Maisha (PALM) study. Two products (Regeneron and MAb114) demonstrated efficacy as compared to the control arm, ZMapp. Very few side effects have been reported. Results from this scientifically sound study led the FDA to license both products, representing a milestone in EVD therapeutic field. These products can be produced relatively inexpensively and can be stockpiled. The administration of mAbs on EVD patients appears ....

Democratic Republic Of The Congo , Democratic Republic Of The General , Bas Congo , Virion Glycoproteins , Nat Microbiol , Ridgeback Biotherapeutics , Ian Crozier , Tshiani Mbaya , Proprotein Convertase Furin , Regional Office For Africa , Development Of Clinical , Ii Writing Group , Leidos Biomedical Research , Ministry Of Health , World Health Organization , Development Of Pan Filoviruses , Its Considerations In Early Development , Feldmannh Progress In Filovirus Vaccine Development , Research Center On Infectious Diseases At Universit , International Commission , Bull World Health Organ , Engineering Therapeutic Bispecific Antibodies Using Crossmab Technology , Central Africa , West Africa , Africa Ebola , Efficacy Results ,