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Frontiers | Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection

1 Abstract The devastating Ebola outbreak in West Africa in 2013-2016 accelerated the progress of several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several IPs were used during that outbreak, but no conclusion on efficacy could be drawn. Only the Randomized Controlled Trial (RCT) on ZMapp was promising but inconclusive. More recently, during the second largest Ebola outbreak in North Kivu and Ituri provinces, Democratic Republic of the Congo (DRC), four IPs (Remdesivir, Regeneron, ZMapp and MAb114) have been evaluated in a RCT, the Pamoja Tulinde Maisha (PALM) study. Two products (Regeneron and MAb114) demonstrated efficacy as compared to the control arm, ZMapp. Very few side effects have been reported. Results from this scientifically sound study led the FDA to license both products, representing a milestone in EVD therapeutic field. These products can be produced relatively inexpensively and can be stockpiled. The administration of mAbs on EVD patients appears ....

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[Full text] Immunotherapeutics for Ebola virus Disease

Taï Forest ebolavirus, Reston ebolavirus, Bundibugyo ebolavirus (BDBV), and
Bombali ebolavirus. Filoviruses are pleomorphic in shape and possess a lipid envelope. The viral genome is a negative-sense single strand RNA which is approximately 19 kb in size.
Since the first outbreak in 1976, EBOV has resurfaced a multitude of times in Africa. Initially, it was responsible for causing small, localized outbreaks until 2013, when the large multinational epidemic was recorded causing 28,646 infections and 11,323 fatalities.
2 A second, large outbreak occurred in the North Kivu province of the Democratic Republic of Congo (DRC) in 2018–2020 totaling 3481 cases and 2299 fatalities.
3,4 There has recently been an outbreak in the Equateur province, which was declared over on November 18th, 2020. ....

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