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Frontiers | Elevated NLRP3 Inflammasome Levels Correlate With Vitamin D in the Vitreous of Proliferative Diabetic Retinopathy

Abstract: Purpose: This study aims to determine vitamin D concentrations in the vitreous and serum, as well as the expression levels of NLRP3 inflammasome pathway in the vitreous of patients with proliferative diabetic retinopathy (PDR). In addition, we investigated the possible correlation between NLRP3 inflammasome levels and vitamin D concentrations. Methods: We obtained vitreous samples before vitrectomy from 55 PDR patients, 25 non-diabetic patients with idiopathic macular hole (IMH), and 10 nonproliferative diabetic retinopathy (NPDR) patients. We also collected serum samples from the same patients. Enzyme-linked immunosorbent assay (ELISA) was used to examine NLRP3 Iinflammasome pathway proteins, including NLRP3, caspase-1, IL-1β, and VEGF. In addition, vitamin D concentrations were analyzed in Roche Cobas 6000’s module e601 platform by electrochemiluminescence immune assay. Results: The levels of NLRP3 inflammasome pathway and VEGF increased dramatically in PDR vitreous. H ....

United States , Kainuu Region , Saudi Arabia , Eteläuomen Läi , San Diego , Bahadir Ozturk , Clin Biochem , J Clin Nutr , Ozben Ozden Isiklar , Clin Endocrinol , Acta Ophthalmol , Hoh Kam , Roche Cobas , Ali Unlu , Ozlem Genc , Leavyo Inflammasome , Software Graphpad , Clin Lab Anal , Endocrine Society , Zhangq Development , Laboratory Assessments , First Affiliated Hospital Of University Science , Glob Health , Vision System Alcon Laboratories Inc , Technology Of China , First Affiliated Hospital ,

Frontiers | Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity

There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms accordi ....

New York , United States , Nordrhein Westfalen , Eteläuomen Läi , Van Houtte , Flexigene Qiagen , Wiebke Diesner , Kurthbm Referenzperzentile , Deutschland Ki , Jens Bauer , Nat Neurosci , Rr Core Team , Mental Health , Ethics Committee No , University Hospital Essen , Millerr Association , Clinical Scientist Program , Software Impacts , Ethics Committee Of The University Duisburg , Adolesc Health , University Bochum , German Research Foundation , Department Of Child , Department Of Pediatrics , Adolescent Psychiatry , Klinikum Essen ,

Intersection between heart and liver a rapidly evolving field

Endocrine Today | About 25% of U.S. adults have nonalcoholic fatty liver disease, which is the most common chronic liver condition in the U.S., according to the American Liver Foundation. Nonalcoholic fatty liver disease, known as NAFLD, can progress to nonalcoholic steatohepatitis (NASH), which is a leading indication for liver transplant. However, most patients with NAFLD die of cardiovascular disease, not liver ....

United States , San Diego , Coll Cardiol , Johannak Distefano , Laurences Sperling , Samuel Klein , Williamh Danforth , Michaelj Wilkinson , University Of California , Emory University , University Of Florida , Uc San Diego Health System , Translational Genomics Research Institute , Washington University School Of Medicine , American Liver Foundation , National Lipid Association Scientific Sessions , Uc San Diego Health , Journal Of The American College Cardiology , Cardiovascular Institute , Emory Center , Circulation Research , American Liver , Nutritional Science , Human Nutrition , Washington University School , American College ,