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Scientists Spot Signs of Multiple Sclerosis Before Symptoms Start

Scientists Spot Signs of Multiple Sclerosis Before Symptoms Start
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People from Mexico show stunning amount of genetic diversity

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Think local. Scientists have mapped the genetic relationships between Mexico’s indigenous groups and discovered a stunning amount of diversity.
A. Moreno-Estrada et al., Science (2014)
People from Mexico show stunning amount of genetic diversity
Jun. 12, 2014 , 2:00 PM
Imagine if people from Kansas and California were as genetically distinct from each other as someone from Germany is from someone from Japan. That’s the kind of remarkable genetic variation that scientists have now found within Mexico, thanks to the first fine-scale study of human genetic variation in that country. This local diversity could help researchers trace the history of the country’s different indigenous populations and help them develop better diagnostic tools and medical treatments for people of Mexican descent living all over the world. ....

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Democratizing DNA-based health risk scores

Democratizing DNA-based health risk scores
Hutch-led consortium receives $9.8M grant to improve genetic risk prediction for cardiovascular disease in racially and ethnically diverse populations
December 10, 2020
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By Diane Mapes
/ Fred Hutch News Service
Photo illustration by Getty Images
For more than a decade, scientists with the PAGE consortium (Population Architecture using Genomics and Epidemiology) have been focused on developing polygenic risk scores those statistical estimates of a person’s risk for disease based on their genes that will accurately predict risk in all major racial and ethnic groups in the U.S.
This is crucial since the Human Genome Project and a lot of the of genetic research done since has focused almost exclusively on people of European ancestry. As a result, polygenic risk scores designed to help clinicians and the general population gauge their susceptibility to ....

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